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Mayo Clinic & Yale University Endorsing Food Sensitivity ALCAT Test

Mayo Clinic

200 First Street Southwest     Rochester, Minnesota 55905    


Robert D. Sheeler, M.D.

Department of Family Medicine

December 1, 2016


Dear Colleague:


I am writing at this time as a Board-Certified Family Medicine specialist in Traditional Western Medicine with over 20 years’ experience at Mayo Clinic where I served as the Medical Editor of the Mayo clinic Health Letter and taught at Mayo Medical School.  I am also writing as a specialist who is Boarded and Certified in Integrative Medicine, Holistic Medicine and Functional Medicine.


I would like to encourage you to look at the attached reprint from Leaders Magazine; an interview with Roger Deutsch, CEO and Founder of Cell Science Systems, which speaks to the existence of a relatively new technology, the Alcat Test, which has recently been independently validated at Yale School of Medicine.  The Yale researchers showed it to be clinically useful diagnostic tool for the identification of foods and other substances that trigger gastrointestinal and potentially many other illnesses.  Its relatively low cost, ease of use, and clinical utility, lead me to believe that its adoption will make a serious dent in healthcare expenditure.  It can serve as a viable complement to conventional approaches to treating many common maladies making diagnosis more accurate and thus relieving much patient suffering.


I commend to your attention the leading-edge testing procedures that have been developed and standardized by Cell Science Systems for identifying food sensitivities.  There are a number of methods that attempt to test for reactivity to food and other substances.  I believe, however, based on the mechanisms involved that the Cell Science System Alcat Test offers distinct advantages in clinical practice.  If it were more widely available I feel that the root cause of a number of different autoimmune, gastrointestinal and system-wide disease states could be improved for many patients.


Thank you in advance for your consideration of this matter.


With respect,

Robert D. Sheeler, M.D.

ALCAT Test & Yale University

Food Reactivity on the ALCAT Leukocyte Activation Test Is Associated with Upregulation of CD11b on T Cells

P01.23 LB Food Reactivity on the ALCAT Leukocyte Activation Test Is Associated with Upregulation of CD11b on T Cells

Ayaz Ghani (1), Wajahat Mehal (1), Ather Ali (1)

(1) Yale School of Medicine, New Haven, CT, USA, May 2014

Purpose: The ALCAT food sensitivity test is based on leuko- cyte activity in the presence of food antigens, though the un- derlying cellular and molecular steps

Conclusion: ‘‘Severe intolerance’’ on the ALCAT test is asso- ciated with an upregulation of CD11b on CD4 + and CD8 + T cells. This study provided detailed analysis of well-characterized cell populations, but was limited to a single time point of anal- ysis. Identification of activation markers can provide a biological understanding of food sensitivity, and may form the basis for more targeted clinical management.

Contact: Ather Ali,

Food Sensitvities vs. Food Allergies

        An allergy is a reaction that triggers the release of antibodies that results in immediate symptom onset. A true food allergy causes an immune response that can affect multiple organs and in some cases, be severe or even life threatening.

        Food sensitivity symptoms are delayed and are typically limited to digestive problems, but they can lead to chronic inflammatory health issues.

TIME MAGAZINE: The Secret Killer

ALCAT Test and Relevance to Chronic Inflammation:  This was the cover of Time Magazine back in February 2004.  The article explains the link between chronic illness and inflammation.

Over the past few years we have came across astonishing evidence relating inflammation to chronic dysfunctions to the endocrine (hormone) system, immune system, and nervous system.  Systems are being altered by inflammation causing abnormal blood chemistry.  Over the past few years inflammation has been linked to cancer, heart attacks, Alzheimer’s Disease, arthritis, inflammatory bowel disease, celiac disease, autoimmune disease, asthma, migraines and many more.

Leaky Gut Syndrome

The ALCAT test identifies delayed or hidden food allergies in various biological pathways

In analyzing the causes of food intolerance, we see that food passes through the intestinal wall then enters the portal circulation, which then passes through the liver.  Toxic components are modified in the liver during a two phase process; transformation and then conjugation with other molecules that allow them to be eliminated from the body.  Those toxins that go through the first phase are called toxic intermediates, and they can be more damaging to the body than the original toxin.  If the second phase of conjugation cannot keep up with the first phase, then some of these toxic intermediates enter the general circulation.  Here the immune system cells take a crack at them.

David Ortiz & The ALCAT Test

Feb 25th, 2012 – David Ortiz, who took the ALCAT test says he has dropped 20 pounds in the past two months and looks like it, is on a diet unlike any that most of you know.

Ortiz, who says his weight is down to around 250 pounds, carries a business card-sized list of foods he cannot eat on his diet, which he started, he said, for reasons that had nothing to do with baseball. His cholesterol had risen to dangerously high levels. “Over 300,” he said.

Weight Loss & ALCAT Test

Food sensitivities knock the body’s biochemistry out of balance.  As we know inflammation in our body contributes to Alzheimer’s, cancer, neurological diseases, autoimmune diseases, arthritis, weight gain and much more.  These inflammatory mediators also have an effect on metabolism, which inhibit the fat burning, or induce the storage of fat and weight loss.  In other words, the chemical reaction of the allergic food seems to prevent the efficient use of fat for energy and weight loss.

With your biochemistry out of balance the metabolism becomes sluggish, the immune system becomes impaired, the digestive tract develops leaks, insulin and other hormones become imbalanced, and the body loses control of the neurotransmitters that control appetite.

Genetic Food Menu

Few recognize the powerful mechanisms that make each person unique.  Inherited difference of hormones and metabolism, environmental variations in exposure to pollution, lifestyle differences of stress, and particular food choices affecting our genetic responses.

It’s know that food and nutrients affect genetic expression.  Every somatic cell contains the entire genome or blueprint for the entire body in its DNA.  A liver cell differs from a skin cell, which differs from a nerve cell, and so on, each cell only expresses that portion of the person’s genome that is involved in the production and function of that particular cell type.  Throughout the entire life of the organism, genetic expression within each cell determines cell, tissue, and organ function.

LIVESTRONG & ALCAT Diet article:  What is the ALCAT DIET?

The ALCAT Diet is a nutritional plan that focuses on avoiding your potential food allergies or sensitivities as opposed to helping you lose weight. This diet plan is usually recommended by a doctor or licensed nutritionist to determine what foods are safe for you to eat on a regular basis, and which items may be harmful to your health.

According to the website, this diet plan was formulated 24 years ago as a test for food sensitivities or allergies. It is used by a wide range of health care professionals during patient treatment..

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“Detection of Food Allergies/Sensitivities, in their broadest definition is always a challenge, because of the numerous immune mechanisms involved. ALCAT testing goes beyond immunoglobulin related techniques, using neutrophil changes to illuminate sensitivities related to a variety of disorders. I have found that some patients’ clinical conditions improve by avoiding foods the ALCAT Test identifies as reactive.”

Allan M Dattner, MD

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